Translational Genomics

Technology & Methodologies

BioVantra employs a multitude of technologies and testing methodologies to provide leading edge DNA, RNA, and protein analysis. This approach allows us to use the technology for each individual biomarker that is most reflective of the clinical literature and scientific evidence. Our technologies and methodologies include:

  • Immunohistochemistry (IHC), the basic tool of molecular pathology. IHC is a type of assay in which specific cellular antigens are detected by the use of labeled antibodies.
  • Quantitative Image Analysis, a computer image analysis technique to decrease the effect of observer biases, and increased usefulness of IHC as a tissue-based procedure for evaluation of diseases. The degree of expression of IHC markers in tissue provides critical information for diagnosis and prognosis.
  • Fluorescence in situ Hybridization (FISH), a technique that uses fluorescent-labeled DNA probes to detect a particular chromosome or gene.
  • CellSearch® Circulating Tumor Cell (CTC) Assay, to aid in the management of cancer patients during therapy. Detection of circulating tumor cells allows physicians to evaluate disease progression and treatment response in patients with metastatic breast, colorectal, and prostate cancers.
  • Transcription Mediated Amplification (TMA), a target nucleic acid amplification method that uses RNA transcription (RNA polymerase) and DNA synthesis (reverse transcriptase) to produce RNA amplicon from a target nucleic acid. TMA can be used to target both RNA and DNA.